The paper focuses on some problems (medical, social, legal) faced by persons with Inborn Gender Identity Disorder Syndrome (IGIDS). The so-called “transsexualism” is a huge problem for persons who “hit the wall” in fulfiling social roles consistent with the perceived gender. It has to be underlined that the social functioning of these persons is extremely difficult, because disapproval of the phenotype/somatic sex hinders their self-fulfilment. The article is based, partly, on the analysis of data from 600 cases of persons with IGIDS who are the patients of one of the co-writer and on the literature of the subject. The main objective of the paper is to point at an important social problem, which is far from achieving an optimum solution. Raising public awareness of the problem is the main motivation of the authors of the paper.