The rapid and ongoing evolution of the COVID-19 pandemic has resulted in reactionary decision-making and emphasized discord arising from uncertainty. Given that countries have dealt with the pandemic quite differently thus far, it was relevant to explore the undertones of decision-making, as well as the perspectives of the individuals who are affected. The study aimed to investigate the role of confidence and decision-making in pandemic behaviors as well as related pandemic perspectives. The present article discusses findings concerning pandemic-specific decision-making, the influence of empathy on decision-making, and qualitative reports from respondents. The analyzed sample included 561 respondents divided into three cultural groups based on response distribution, geography, and general cultural categorizations (e.g., Western vs. non-Western). The findings revealed insights into the decision-making of pandemic consequences, as well as a lack of cross-cultural differences within the sample. Subjective reports highlighted key themes including trust in science, prevention and preparedness, and suggested next steps from the respondents’ perspectives. These findings from across the globe call for further investigation into cross-cultural decision-making in the pandemic.